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Fig 1. Schematic representations of the architecture of the Rossmann fold.

The Rossmann is a β/α fold, namely a consecutive repeat of motifs comprising a β-strand (in yellow), a connecting loop (green), and α-helix (orange). The β-strands form a core β-sheet with the strands in the distinct order of 3-2-1–4-5-6. In effect, the Rossmann fold comprises two consecutive repeats, each comprising three β-strands (3-2-1 and 4-5-6), and two connecting α-helices. Shown in a red sphere is the ribose-binding Asp/Glu residue analyzed here, which resides at the tip of the second β-strand. Note that the Rossmann fold is usually addressed in the wider context, including Rossmann-like, or Rossmanoids, in which the sixth strand is missing, or is modified with additional secondary structural elements (e.g., methyltransferases).

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Overall, a common fold [ 20 ] and the shared binding motif (the ribose β2-Asp/Glu interaction) are highly suggestive of a common Rossmann ancestor and specifically of common ancestry of NAD-, FAD-, and SAM-utilizing enzymes [ 30 , 34 , 38 ]. Indeed, these three classes (and a few additional ones addressed below) are all present in the presumed LUCA [ 48 , 49 ]. However, so far, there has been no attempt, to our knowledge, to examine whether these shared features are indeed a hallmark of common descent [ 39 ]. Such a systematic analysis is crucial in view of convergence being common and especially because the shared binding motif comprises a single residue.

We were initially interested in engineering the SAM-binding site of DNA methyltransferases—a Rossmann-fold enzyme superfamily. Our attention was focused on the adenosine group that appears in nearly all of the key enzymatic cofactors. In this context, we were searching for a highly conserved interaction that is critical to adenosine binding and could be modified. However, our analysis indicated that none of the residues that interact with the adenine ring are conserved in all DNA methyltransferases. In contrast, we observed that a Glu residue that interacts with the ribose is entirely conserved. We first observed that the carboxylate-ribose interaction is completely conserved in SAM-dependent methyltransferases, including DNA, RNA, protein, and small molecule methyltransferases. We realized that conservation does not simply concern an active-site Asp/Glu that interacts with SAM [ 42 , Aska Suede KneeHigh Boots Discount 100% Guaranteed Buy Cheap Visit Buy Cheap Clearance Cheap Prices Reliable Cheap Sale Shop Offer RBsAhQ4r
] but primarily relates to a bidentate interaction with the ribose’s 2ʹ and 3ʹ hydroxyls with an unusually narrow distribution of H-bond distances and angles. Distinctly, the interacting Asp/Glu is at the tip of the Rossmann’s second beta strand (β2) ( Buy Sale Online Tory Burch Logo Rain Boots Best Store To Get Cheap Online Cheap Big Discount How Much Cheap Price WFIaKkLS
; S1 Fig and S2 Fig ). Further, although the β2-Asp/Glu was described as a characteristic of Rossmann NAD dehydrogenases [ 44 ], its bidentate nature has not been described as such.

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AT A GLANCE: WHICH FOODS ARE MEDITERRANEAN-STYLE DIET STAPLES?

A Mediterranean-stye diet is known for its triglycerides-lowering effects. Along with the tips provided above, see also the book , which offers the following summary.

“The countries surrounding the Mediterranean Sea each have their own traditional foods. Thus, there is no single Mediterranean diet. For this reason, we refer to the dietary patterns in this diverse region as a Mediterranean-style diet.

“The following selections characterize a Mediterranean-style diet:

The book also notes that Mediterranean-style diets are associated with improved cardiovascular health as well as reduced risk of stroke. “When researchers reviewed 50 studies conducted in the United States, Australia, and Greece, they found a link between a Mediterranean-style diet and protection against metabolic syndrome, a cluster of health problems including high blood pressure, elevated blood sugar, abnormal blood cholesterol and triglycerides, and excess abdominal fat.

In addition, a Mediterranean-style diet has been linked with a lower incidence of specific heart conditions, including sudden cardiac death (triggered by a dangerously fast heartbeat). Newer research links the Mediterranean-style diet with protection against age-related macular degeneration, which is the leading cause of blindness in older Americans. Furthermore, preliminary research suggests the Mediterranean diet may help reduce the risk of breast cancer.”

is published by the editors of in conjunction with The Friedman School of Nutrition Science and Policy Tufts University.

[1] American Dietetic Association, 2008; 108 (12): 2059.

Originally published in 2012, this article is regularly updated.

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Breaking News

October 20, 2016 | 10:11 AM
by Danielle Harling
HipHopDX/Cindy Barrymore - @cindybarrymore

Seattle, Washington – There will be no , according to Kanye West , and Apple and TIDAL are to blame.

While speaking to the audience at the Saint Pablo Tour stop in Seattle, Washington this week, ‘Ye declared that there “will never be a ” because of “TIDAL/Apple bullshit.”

The Chicago superstar also revealed that he gets heated every time he performs his verse on “ Pop Style .”The versedidn’t make the cut forthe album version of the record from Drake.

“It will never be a ,” Kanye West said. “You know why? Because that’s the reason why I wasn’t on the song. I wasn’t on the song cause of Hov. Cause it’s this TIDAL/Apple bullshit. And this shit be getting me tight every time I perform this muthafucka.”

Kanye continued to drop knowledge on what really happened with The Throne’s contribution to Drake’s “Pop Style,” and it turns out it was politics as usual.

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“We sent it back to [Drake],” the rapper said. “And he’s like ‘Oh shit, The Throne is on this shit.’ Then Jay thought about it. Out of respect for Meek Mill, he didn’t want to be on the track. And I said ‘Look, I’ll call Drake. I’ll call Meek. I’ll call y’all. We gotta squash this shit. We gotta let the people have this song.’ But then it went out of that [category]. It went into some TIDAL. Some shit, some political shit about percentages on songs. I can’t take this shit, bruh.”

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on why ‘Ye and Jay were left off of the version of “Pop Style.”

“Jay didn’t really do a verse,” Drake said, during an interview with Zane Lowe in April. “Really I just was trying to get ‘Ye on it at first. And ‘Ye just sent it to me like that. Like ‘Yo, Jay kinda just did my first few lines for me. And he was just here. And that’s how we flexed it.’ It was cool … I mean, of course people wanna hear Jay Z rap. So, hearing him do two lines might be frustrating to a certain audience.”

ye talking about Watch The Throne 2 Apple/Tidal problems @TeamKanyeDaily #SAINTPABLO pic.twitter.com/kXZNZuvTfP

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> News Releases > SsangYong Rexton ‘storms’ the 4×4 Magazine Awards

January 12, 2018

The SsangYong Rexton has swept the field aside to win ‘4×4 of the Year 2018’ in this month’s 4×4 Magazine, while also romping off with the Best Value award and Off-Roaders class for best-overall off-roader.

Established over 25 years ago, 4×4 magazine’s 4×4 of the Year awards have become recognised as the leading experts’ verdict on the best vehicles in the SUV, pick-up and off-road market.

Commented Alan Kidd, editor of 4×4 magazine: “We were genuinely surprised at how good the Rexton is. The combination of kit, styling, practicality and build quality is nothing short of remarkable; it would be impressive at twice even three times the price.

“The Rexton won the Off-Roaders class despite strong competition from rivals as diverse as the Jeep Wrangler JK and Toyota Land Cruiser, and was the best all-rounder.

“Competition for the overall title this year was fiercer than ever, with strong contention from the Land Rover Discovery, Vauxhall Insignia Country Tourer and Skoda Kodiaq. It speaks volumes for how well the Rexton did to beat them, and is clearly something very special indeed.”

Said Nick Laird, managing director of SsangYong Motor UK: “For an all-new car launched just four months ago to do so well against such established and strong competition, is a truly impressive result. SsangYong likes to think of the brand as ‘Korea’s Land Rover’, and now with complete justification! It’s great to see a strong product also getting great recognition.”

Concluded Alan Kidd, “SsangYong doesn’t just sell on price any more. There’s a confidence about its products which bodes well for the future. The Rexton is the most profound example of this we’re yet to see.”

SsangYong Rexton The all-new Rexton, SsangYong’s flagship SUV 4×4, was launched in the UK in the autumn, heralding major advances in style, quality, safety and technology for the brand.

Impressing with its sheer presence and beautifully balanced exterior, new Rexton is a large D/E-segment four-wheel drive offering a prestige cabin for passengers to travel in supreme comfort, while disguising its tough and rugged off-road capability.

Representing a huge step forward in every area – looks and style, interior ambience, structure and safety, performance and technology, this new car stays true to SsangYong’s core brand values with extremely competitive pricing from £27,500 on the road.

The new car is an authentic 4×4. It is powered by a 2.2 litre turbo Euro 6 diesel engine delivering maximum power of 181PS and maximum torque of 420Nm, with a 6-speed manual or 7-speed Mercedes-Benz automatic transmission, and features a 3.5 tonne towing capacity, the benchmark for those who tow large caravans trailers.

Stylish inside and out, the new car has gracious looks, and with a contemporary interior that’s trimmed in quilted Nappa leather. Built using a modern and extremely strong body-on-frame construction, it is extremely safe and comes equipped with a comprehensive suite of electronic safety aids, and up to nine airbags.

With the latest in connectivity and technology, new Rexton features Apple CarPlay and Google Android Auto, an HD 9.2” navigation screen and 3D ‘around-view’ monitoring.

This fourth generation Rexton draws on SsangYong’s heritage and deep experience of building 4×4 vehicles over 60 years, and as well as its highly competitive pricing and comprehensive list of standard equipment, features an industry leading 5-year limitless mileage warranty.

About the 4×4 Awards The 4×4 Awards were established at a time when every 4×4 was an out-and-out off-road vehicle, and early editions concentrated solely on this element. Over time, however, they have evolved alongside the 4×4 market itself to reflect the growth of SUVs and crossovers, placing a heavy emphasis on practicality and everyday use in addition to a relevant level of off-roading.

Maisie Priestner

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